A preliminary study of the submandibular gland of the rat after one-year cadmium intoxication. Part I. Cadmium concentration.
نویسندگان
چکیده
The aim of the present study was to establish to what degree a one-year exposure of rat females to 5, 50 and 100 mg Cd/l affects the weight of the submandibular glands and their cadmium levels. We observed a decrease in the weight of the submandibular glands in the rat females from Groups I, II and III, compared to the control rats. We also found an increase in cadmium levels in the submandibular glands in Groups I, II and III, in comparison to the control. The highest cadmium concentration was noted in the submandibular glands in Group III, which was accompanied by the greatest weight reduction, the correlation being negative. The present experiment indicates that one-year administration of cadmium to rat females at a dose of 5, 50 and 100 mg Cd/l leads to a cadmium dose-dependent decrease in the weight of the submandibular glands.
منابع مشابه
A preliminary study of the submandibular gland of the rat after one-year cadmium intoxication. Part II. Pathomorphology and ultrastructure.
The aim of the present study was to establish to what degree a one-year exposure of rat females to 5, 50 and 100 mg of Cd/l affects cell morphology of the submandibular glands. After one-year cadmium exposure of female rats, at doses of 5, 50 and 100 mg Cd/l, a pathomorphological examination revealed periductal fibrosis in the submandibular glands of rats in all the three experimental groups, w...
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The aim of our study was to determine to what degree one-year exposure of female rats to cadmium at a dose of 5, 50 and 100 mg Cd/l affects cell proliferation in the submandibular gland, shown by PCNA and Ki-67 expression. In the present study, we found a positive nuclear reaction for PCNA in single cells in microscopic preparations of control rats. In Group I, an increase was observed in the n...
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The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm3 affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm3, while the group II animals were given 50 mg Cd/dm3. The highest co...
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PURPOSE Cadmium toxicity in the exposure of the general, professional and cigarette smoking populations has been well known. From the dental point of view, it is important to find out whether and how separate and joint exposures to cadmium and zinc affect the structure and function of the submandibular gland, which is the major saliva-releasing gland. Cadmium, a particularly active xenobiotic, ...
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ورودعنوان ژورنال:
- Roczniki Akademii Medycznej w Bialymstoku
دوره 49 Suppl 1 شماره
صفحات -
تاریخ انتشار 2004